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Strikingly, FFFF I/R mice showed a progressive deterioration of cardiac function from 2 to 4 weeks post-surgery, while this functional impairment was ameliorated in DKO mice after 4 weeks (Fig 5B).
While this functional evidence supports the implication that cell fusion can create a genetically distinct hybrid cell, the extent of reprogramming of the genome remains an intriguing and important future focus of investigation.
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Stretching vibration, which was detected in all of the DESs, was the most common vibration for this functional group, while in-plane bending vibration was detected in only a few types, as shown in Table 3.
While the functional consequene of this described point mutation is unknown, this and our work at least indicate that mutations in WTX might be involved in colorectal carcinogenesis in a small proportion of both, MSI-H as well as MSS tumors.
While the functional significance of this remains to be fully determined, the trend can be explained, in part, by creation of male-biased genes through retrotransposition.
While the functional consequences of this remain to be explored, the implication of both AR and ERG oncogenenic signalling axes provides further weight for the importance of the HES transcriptional network in prostate cancer.
While the functional outcome of this pathway may be both protective and destructive in tumor cells, the protective effects of the proteotoxic stress response can be pharmacologically blocked to promote tumor cell death.
Analysis of embryonic RD gene expression in two endopterygotan insects, A. mellifera and D. melanogaster, did not show evidence for coordinated gene expression, therefore while the functional significance of this gene cluster remains unknown its maintenance during insect evolution implies some functional significance to the cluster.
While the functional basis of this response is not entirely clear, these findings indicate that CagA-medicated REG3γ overexpression may abolish the fitness of co-habiting Gram-positive bacteria and reduce the competition for resources between H. pylori and Gram-positive bacteria in the gastric mucosal niche.
While this measure included functional items which is beyond the scope of this review the most difficult items were memory items which is in line with previous findings.
While this represents the functional outcome of several genetic mechanisms of PTEN loss, IHC relies on subjective interpretation and has the potential for inter reporter variation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com