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Indeed, because esg-Gal4 is expressed in both ISCs and their immediate progeny (the EBs) for some time while they differentiate, it is possible that the clock regulates EB-to-ISC signaling.
Therefore, in addition to avoiding dedifferentiation and unrestricted tumorigenic overproliferation, INPs need to overcome another challenge to avoid over-differentiation and cell cycle exit in order to maintain their progenitor state and self-renewal while they differentiate to mature and undergo self-renewing divisions.
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Angioblasts subsequently produce the endothelial cells that line the vasculature during both vasculogenesis and angiogenesis, while hematopoietic progenitors differentiate into distinct blood lineages through hematopoiesis.
We confirm sex-based differences in heart rate and PR interval of adult mice while establishing when they differentiate, at two different points in development.
Paneth cells appear during early postnatal life and they differentiate while migrating towards the crypt base, where they reside for about 20 days before being cleared by phagocytosis [25].
CFU-E numbers after EPO treatment were increased greatly and then decreased progressively while they were differentiating to proerythroblasts.
It has taken me a while to differentiate between the staff, to learn their names, but now I always hope to get Sue on the phone if I call.
In this study we have shown that ES-derived neurospheres (ES-NS) are able to generate specific phenotypes under the influence of diffusible factors in vitro, while they fail to differentiate after transplantation in the gut.
Stem cells are capable of renewing themselves to maintain a stem cell pool as a preserved cell source for tissue homeostasis, while they can also differentiate into mature cells to carry out the function of a specific tissue.
They migrate to reach the rostral end of the intestine and enter the mesodermal layer, in which they migrate rostrocaudally and circumferentially along the GI tract, continuing to proliferate while they migrate and to differentiate into a variety of neuronal subtypes (Furness, 2006).
Businesses will finally be able to separate the IT functions they need to differentiate, while commoditising everything else, and manage them both in exactly the same way.
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