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Another limitation is that while the study was ongoing, a new draft HSSP was issued for comment.
Additionally, the instructors and the researchers did not know which students were assigned to the treatment or control groups while the study was ongoing.
Following a regulatory request regarding the tocilizumab development programme, immunogenicity testing was introduced to ACT-RAY while the study was ongoing.
While the study was ongoing however, it appeared that two of the eight patients allocated 33 mg m−2 dose experienced DLT in cycle 1.
An open-label study design was employed so that the study could be amended or terminated if any treatment groups experienced unexpected trends in the incidence or severity of adverse events while the study was ongoing.
We are also indebted to Ardelio Galletti, PhD, for his assistance with the statistics and to Roberto Paludetto, MD, for his constant supervision of the NICU clinical activity while the study was ongoing.
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While the study is ongoing first results show a high potential for the large scale solar system being a feasible concept for the urban district heating of Graz.
While the intervention assignment and the individual mammography outcome is not blinded, overall study arm outcomes will be blinded for all study personnel while the study is ongoing.
In the unfortunate event of a patient's death, while the study is ongoing, a condolence card will be sent to the bereaved family.
Such complexities include protocol amendments (changes to inclusion and exclusion criteria for patient characteristics while the study is ongoing) and the need to close study centers in some countries and open new centers in other countries (resulting in the need for translations, which cause time delays).
The study is ongoing but has already produced valuable insights.
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