These results suggest that NO is mainly involved in the inhibitory action of LPS on stimulated-PI hydrolysis in the early stage, while in the later stage, a factor(s) besides NO causes attenuation of the stimulated-PI hydrolysis.
During the early stage of ethylene propylene copolymerization, with lower content of copolymerized ethylene (7.4 mol%), the EPR phases occur only in the external layer of the particle, while at the later stage of the copolymerization with higher content of copolymerized ethylene (26.7 mol%), the elastomer phases distribute uniformly in the whole particle.
As suggested by Labiano et al. (2006), during their experiment on limited pressurized operation, an increased pressure during the startup helps to improve the reduction reactions of oxygen carrier (similar to reaction Nos. 2 & 4) while at the later stage it exhibits a negative impact on coal devolatilization reaction.
But there is a directionality in the sense that the earlier stages have the later ones as their telos, or goal, while the later stages both presuppose and include the earlier ones as important but subordinate moments.
In the proposed cascade structure, the earlier several stages are based on the more efficient un-occluded features to assure a high detection speed, while the later stages are based on both the un-occluded features and the reconstructed occluded features for better classification performance.
While the later stages of the PhAT deal with the clinical validation of the therapeutic hypothesis, early preclinical experiments are essential to define a number of the PhAT parameters, including identification of biomarkers and early demonstration of efficacy and proof of mechanism.
The initial period of polarized growth forms the narrow neck, while the later stages form the subsequent swelling at the base of the round bud.
10 14 20 It has been hypothesised that the earlier stages of burnout are characterised by increased levels of free cortisol, while the later stages are associated with lower than normal cortisol levels, representing a breakdown of endocrine feedback mechanisms.
The initial steps of metastasis require the acquisition of a motile phenotype in order to traverse tissue boundaries, while the later stages require dynamic adhesive interactions with the extracellular matrix to facilitate the extravasation of malignant cells [ 1].
Soon after the ischemia, macrophages of the M2 phenotype were present and exerted neuroprotective effects; while being at the later stage of injury, the M2 phenotype gradually transforms into the M1 phenotype and is involved in neuronal damage.
