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The expected banks of switches and flashing lights have been replaced with "ambient sky-blue LED lighting" and smoothly curving walls, while the bulky straps of the old seats have been removed in favour of leather contraptions that look like they could double up as gym equipment.
The results suggest that the sinusoidal channels are exclusively filled by TMA, while the bulky SS-bmpm cations can only be accommodated within the MWW super-cages, thus providing a new example of cooperative structure-directing effects of small and bulky cations in the synthesis of complex zeolite structures.
A high working voltage of ≥ 3 V was realized using an ionic liquid-based electrolyte (ILE), while the bulky organic molecules showed unfavorable diffusion kinetics [7 9].
Tall LED headlamps evoke those of current Cadillacs, while the bulky, triangular rear evokes the tapered, streamlined hind quarters of the Volkswagen XL1.
The use of the long alkyl, aryl, phenylene, polyethylene glycol, or heterocyclic chain allows the indomethacin functionality to fully insert into the binding pocket of COX-2, while the bulky fluorescent secondary amide functional group projects through the constriction at the base of the active site and into the wide lobby in the membrane-binding domain.
While the bulky DB[ a, l]P moiety with its five aromatic rings resides in the B-DNA minor groove and points toward the 5′-direction of the modified strand like the analogous B[ a]P moiety, its accommodation in this groove is very different.
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But it is also trying to sell the handy little Mini Disc machines as strictly for use on the move, while the bulkier CD player remains at home.
Interestingly, the rather linear 4-cyanosubstituted compound 1s (IC50 = 50 μM, entry 19) had encouraging activity, while the bulkier 4-methylsubstituted analog 1t (entry 20) was inactive, providing further evidence for a rather small and linear binding pocket of ATGL.
As illustrated in the oval region, the small groups, positive charged groups and hydrogen bond acceptor are favorable for improving activity, while using the bulky hydrophobic groups or hydrogen bond donor at the rectangle place is beneficial to promote the bioactivity of the molecules.
Compound 3, with the saturated lactone ring, displays the next lowest decrease in potency, while 4, with the bulky acetonide group on the steroid core, shows the greatest decrease in potency.
Though the specifications of the Redshift machines are similar to those of conventional dirt bikes, with full-size wheels, fully adjustable suspension and 12 inches of wheel travel, the frame is a proprietary monocoque, or stressed-skin design, engineered for stiffness and light weight while making room for the bulky batteries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com