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In breast CSCs, treatment with disulfiram and copper can inhibit consitutively active NF-κB while sensitizing these cells to paclitaxel [91].
Addition of Z-VAD-fmk may block apoptotic cell death while sensitizing cells to necrotic or autophagic cell death [23].
DW-EPI images are acquired using relatively high 'b' values to 'desensitize' the sequence to fast moving protons such as those within blood vessels while sensitizing them to less mobile protons in the extra- and intra-cellular spaces[39].
Exogenous IL-2 supplementation to isolated CD25+ T cells has a remarkable anti-apoptotic effect on CD25+ T cells (p<0.001, Figure 2A) while sensitizing CD25− cells to apoptosis (p<0.001).
We believe that autophagy induction should promote survival of the healthy cells while sensitizing cancer cells to cytotoxic drugs, providing a very attractive therapeutical approach.
From a therapeutic perspective, 4-PBA might provide a means to protect other cell types from amyloid deposition while sensitizing the AL amyloid-producing plasma cell to agents that induce cell death via non-ER stress mediated mechanisms.
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Thus, the genotoxic activity of doxorubicin activates the internal apoptosis pathway, while simultaneously sensitizing the cell to external, receptor-mediated apoptosis by the TRAIL ligand.
Death receptors are not involved in GTN-mediated cell death, while GTN sensitizes tumor cells to Fas-ligand induced apoptosis.
While prostaglandins sensitize nociceptors and eventually promote CGRP release, triptans inhibit such release, thus producing an indirect anti-migraine effect, and CGRP antagonists abrogate the final common pathway of migraine mechanism.
Both sera of soya-allergic patients activated the basophils upon incubation with Gly m 4, while cells sensitized with three of the four soya-tolerant patients' sera did not react with Gly m 4 (Fig. 3B).
All of the children without asthma had dust mite allergen concentrations under the sensitizing threshold, while over two-thirds of children with current asthma were above this concentration.
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