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While it is not straightforward to compare these methods using the same quality criteria, most of them seem to perform well for classification purposes.
While it is not straightforward to simulate indirect effects (since both the X→ M and M→ Y relationships need to be specified and, hence, there are a lot of specifications to be made), as a sensitivity analysis we performed some post- hoc power calculations, given the same within-stock sample sizes and using the same lifespan means and spreads.
But professionally there have been disappointments, while, personally, life is not straightforward either.
While their interpretation is not straightforward, it is still worth to briefly comment them.
Comparison with the Zhao results is not straightforward: while they achieve at best 70% sensitivity at the 100% specificity level using microarray data, their best result is 90%/100% sensitivity/specificity but only for one patient group (AA) and using RT-PCR data.
While exploiting the loophole was not straightforward, said the researchers, there was evidence that it was being abused in Egypt to harass some dating app users.
However, small RNA populations in all organisms are extremely complex; while accurate miRNAs identification is not straightforward.
It should be stated here that the perception of organisational goals while performing the security procedure was not straightforward in actual driving conditions.
The MP said the issue was "not straightforward", saying that while there was "absolutely no question" that industries like whisky must be protected, some countries see geographical indications as barriers to trade.
And while I know the answer is not straightforward or simple, I also know that we cannot interrupt, dismantle or undo a problem until we become aware of it.
Policymaking is not straightforward.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com