Only bone-targeting lines were successful in migration through rigid matrigels, while lung-targeting SCPs invaded only through soft matrices, and non-metastatic lines showed no ability to invade.
While lung-cancer screening trials using chest radiography have reported inconsistent findings [ 4– 6], several studies using low-dose computed tomography (LDCT) scans have led to a re-evaluation of screening programs.
In BM-derived resting and IFN-γ-activated cells, the growth kinetics of Mtb were similar between WT and Ifnar1−/− cells, while lung-purified macrophages revealed minor differences (Supporting Information Fig. 6A).
For example, 'abnormal cell proliferation' is a phenotype while 'lung cancer' is a disease, 'increased adipogenesis' is a phenotype while 'obesity' is a disease and 'decreased blood pressure' is a phenotype, while 'idiopathic orthostatic hypotension' is a disease.
At CTD, we refer to these non-disease events as phenotypes (e.g., 'abnormal cell proliferation' is a phenotype while 'lung cancer' is a disease; 'increased adipogenesis' is a phenotype while 'obesity' is a disease).
