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The polymer coat was designed to protect the particles from decomposition while in circulation but enable their activation at lower pH values in hypoxic regions of solid tumours.
However, efficacy and safety can potentially be compromised due to the release of conjugated drugs from the ADC with time while in circulation, resulting in changes in the drug-to-antibody ratio (DAR).
While in circulation, the LCs misfold into amyloid fibrils which in most cases (85%) are composed of the N-terminal variable domain [3].
A more plausible explanation would relate to tumour-induced suppression of DC populations while in circulation.
The HBPE-NPs protected CT20p while in circulation and allowed efficient uptake by targeting tumor cells.
In mice, blood monocytes newly released from the bone marrow are exclusively Ly-6Chigh and the level of Ly-6C is downregulated while in circulation [ 45].
Similar(48)
But while Ms. Andreen's offerings share a theme — the "Love" box was the one being shown in Times Square, while the others in circulation are "Potty-Mouth Comedies," "Fantastic Films," "Powered by Girls" and "Zombies" — they face other hurdles.
Old ideas of "western" and "developing" countries, or that it's possible to think of sub-Saharan Africa as any kind of homogenous bloc, are completely debunked, even while they remain in circulation in our media.
The Browns retired his number 14, while 60 remains in circulation.
Censorship only comes into play once a text has actually been in circulation for a while, only after a number of readers have found a published text to pose a threat.
There were more than 200 different images of the author in circulation while he was alive, making him instantly recognisable.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com