Sentence examples for while having minimal effect from inspiring English sources

Specifically, during extensive mechanical assessment elastin was found to reduce the specific tensile and compressive moduli of the scaffolds in a concentration dependant manner while having minimal effect on scaffold microarchitecture with both scaffold porosity and pore size still within the ideal ranges for tissue engineering applications.

FGF19 infusion in WT mice reduced free and taurine conjugated cholic acid (CA) and the CA-derived secondary bile acid deoxycholic acid, while having minimal effect on chenodeoxycholic acid (CDCA) metabolites, muricholic acids (MCA).

Pretreatment of cells with ultrasound (20 kHz, 2 W cm−2, 60 s) selectively induced cytotoxicity in skin and prostate cancer cells, while having minimal effect on corresponding normal cell lines.

A small molecule compound was discovered through high-throughput screening as a potent inhibitor of bcr-abl and it was then developed into Gleevec, a commercial therapy for inhibiting bcr-abl to block tumor growth while having minimal effect upon normal cells.

Our findings suggest that changes in the surrounding matrix can influence catabolic genes in tenocytes when cultured in a complex strain environment mimicking that of tendon, while having minimal effects on tendon and homeostatic genes.

This final drug combination synergistically inhibited ECRF24 viability, while having minimal effects on non-endothelial cell types.

At this concentration flupirtine evokes nearly 50% of its maximum pulmonary vasodilator effect (25) and activates Kv7 channels, while having minimal effects on a number of other ion channels (26).

Indeed, RNA interference of MAP1D altered anchorage-dependent growth of colon cancer cells [ 12] and inhibition of PDF with actinonin and numerous analogs decreased proliferation of many cancer cells while having minimal effects on non-cancer cell lines [ 13].

Based on these results a concentration of 500 μM NHS-biotin was chosen for the following studies as it is sufficient for modification of solvent-accessible lysine residues of XPA to prevent binding while having minimal effects on complex integrity.

Our findings show that FASN inhibition selectively inhibits growth and viability of tumor cells both in vitro and in vivo, while having minimal effects on non-tumor cells such as fibroblasts and endothelial cells, and demonstrate that tumor cells have a unique dependence on FASN function for survival that is not present in normal cells.

While this has minimal effect on our network dynamics and no effect on our blocking of re-replication, it would provide a better resolution of events at origins just prior to the G1/S transition.