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SCK NPs with shell silver cation-load only, while efficacious in vitro, failed to demonstrate efficacy in vivo.
High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has emerged as a treatment for MDD, and while efficacious, the daily commitment for typical 4 6 weeks of treatment poses a significant challenge.
In contrast, combined HDACi/rhTRAIL-based strategies, while efficacious, demonstrated on-target dose-limiting toxicities that precluded prolonged treatment.
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Although derived from the glucocorticoid cortisol acetate, it was designed to be devoid of glucocorticoid activity while retaining efficacious anti-angiogenic activity.
While demonstrably efficacious, there several barriers to attending face-to-face therapy in the Australian setting.
Live attenuated influenza vaccine (LAIV), while more efficacious in young children than inactivated vaccines, is of limited utility due to its safety profile in the pediatric population under two years of age.
While they are efficacious for psychotic symptoms, their efficacy is limited for negative symptoms and cognitive deficits which underlie the substantive disability in this illness.
Initial reports with Dysport suggest that the while it is as efficacious and safe as Botox, the primary potential benefit is that a small subset of patients may have a very prolonged effect with normal dosage (eg, greater than 6 months).
This observation has provided further opportunity to investigate the reasons why in the in vivo assay model INH was highly efficacious while when tested in the in vitro assays it lacks efficacy against MIP even at higher concentrations.
To overcome this limitation, it was hypothesized that an α1a/1d subtype-selective antagonist would be efficacious while keeping side effects to a minimum.
The administration of a therapeutically more effective dose of nal-IRI (i.e., 20 mg/kg), while safe and efficacious [35], would have reduced sensitivity in the measurement of FAZA uptake due to potential disappearance of tumor hypoxia following partial or complete response and could also have introduced measurement bias due to rapid tumor volume shrinkage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com