Exact(1)
Figure 7B and C shows that MT stabilization with Taxol did indeed result in decreased separation in M but not G2 phase, while destabilization of MTs in a low Nocodazole dose did cause an increase in separation in G2-arrested cells but had little effect on M-phase cells.
Similar(58)
While the destabilization of the Larsen C Ice Shelf is certainly worrying, it pales in comparison with the threat from the increasing instability of the glaciers and ice shelves holding back the enormous West Antarctic Ice Sheet.
The stabilized stem-loop totally inhibited translation in both growth phases (No. 8), while mutational destabilization led to a constitutive high level of translation (No. 9).
While protein destabilization is required for hydrogel formation, too much denaturation becomes a hindrance to protein functionality and biocompatibility.
M1 macrophages (classically activated macrophages) and foam cells, secreting proinflammatory molecules such as IL-1 β, MMP-9, or TNF- α, play central role in plaque progression, thinning fibrous cap, and plaque destabilization, while M2 macrophages (alternatively activated macrophages) are associated with anti-inflammatory responses with IL-10 or TGF- β [ 77, 78].
Laminoplasty has been developed to decompress the spine posteriorly while avoiding the spinal destabilization seen after laminectomy.
The XP/CS features may result from dissociation of CAK from TFIIH, while a more global destabilization of TFIIH involving XPD dissociation would give rise to TTD.
In the former, the microorganism provides the most favorable working environment for the enzymes by (1) availing all necessary cofactors and regeneration networks; and (2) providing sufficient protection of enzymes from effects such as destabilization and degradation, while allowing both the substrate and product to cross the membrane barrier (Jose et al. 2012).
These early changes in the interfacial behavior of the protein were attributed to disruption of long-range interactions and to destabilization of AS, while the subsequent changes were related to the onset of oligomerization.
VEGF also stimulates, while Ang1 counteracts Src-mediated destabilization of paracellular VE-cadherin junctions and IP3/eNOS-mediated calcium influxes in ECs which together cause vascular hyperpermeability and lowered resistance to TC diapedesis (Gamble et al, 2000; Gavard et al, 2008; Le Guelte et al, 2011; Koh, 2013).
Some groups have observed a requirement for the production of reactive oxygen species through NADPH oxidase while others have identified a destabilization pathway of lysosomes, whose content is released into the cytosol (Cassel et al, 2008; Dostert et al, 2008b; Halle et al, 2008; Hornung et al, 2008).
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Justyna Jupowicz-Kozak
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