Development of quantitative PCR (qPCR) has enabled detection and quantification of the target sequence in real time, while it is being synthesized.
Under the transcription model, while RNA is being synthesized on the transcribed strand of DNA, the nontranscribed DNA strand remains transiently single stranded.
We have shown that this interaction is specific and is not captured while Ire1α is being synthesized in the Sec61 translocon since the other ER stress sensors, Ire1β, PERK or ATF6, fail to interact with the Sec61 translocon.
Isolated mitochondria preparations cannot make NAD from NAM, and while NAD is synthesized from NMN, it does not localize to the mitochondrial matrix or effectively support oxidative phosphorylation.
A telechelic functionalized acrylate oligomer was obtained by acrylation of α,ω-fluorinated hexanediol, while SPEEK was synthesized by polycondensation of sulfonated difluorobenzophenone with the bisphenol 6F.
Novel flame-retardant curing agents for epoxy resins, [ODOPM PN] and [ODOPM MPN], were prepared from phenol formaldehyde novolac (PN), melamine-phenol formaldehyde novolac (MPN) and a reactive 2- 6-oxid-6H-dibenz〈c,e〉 〈1,2- 6-oxid-6H-dibenz〈c-methanol (ODOPM) while ODOPM was synthesized through the reaction between 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and formaldehyde.
2- 6-Oxid-6H-dibenz〈c,e〉 〈1,2- 6-Oxid-6H-dibenz〈c)1,4-benzenediol (ODOPB) was prepared by the addition reaction between 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and p-benzoquinone while DOPO was synthesized through multistep reaction from o-phenylphenol and phosphorus trichloride.
While cholesterol is synthesized in the ER, less than 1% of total cholesterol is located in the ER [41, 47].
(St . Louis MO), while 7DHP was synthesized and purified as described [1].
DAG is considered a primary inducer of insulin resistance in response to excess unsaturated fat feeding [30], [31], while ceramide is synthesized directly from saturated fatty acids and antagonizes insulin action in muscle [4].
