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This was done to minimise the availability of TRP from food which would counteract the effects of the acute treatment.
Smoking, however, has an anti-estrogenic effect through the formation of inactive 2-hydroxy catechol estrogens [ 30], which would counteract PADs.
Rescue factors may be also communicated from the bystander to the irradiated cells, which would counteract the propagation of signalling molecules that lead to harmful bystander responses.
In both healthy humans and patients with pre-existing hyperglycemia and hyperglucagonemia, exogenous GIP is reportedly glucagonotropic, which would counteract any insulinotropic effect (6, 8, 11, 15).
This involves in vivo or ex vivo induction of tumor-reactive T cells, which would counteract systemic and local immunosuppression in tumor-bearing hosts.
Careful dose-finding studies in cancer trials targeting Plk1 are necessary to prevent the inhibition of DAP kinases, which would counteract the pro-apoptotic effect of Plk1 inhibition.
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Reeve and Tyrrell also reported the induction of IL-12 by UVA, which they proposed would counteract the UVB- induced immunosuppression through the hemoxygenase 1 pathway.
Moreover, genetic drift modifies allelic frequencies randomly, thus equally leading to beneficial or detrimental changes in individual fitness, which would tend to counteract the effects of selection.
St Denis diagnosed "a dangerous facility which would need counteracting with discipline", a complaint drama critics were to make all Ustinov's life.
To probe the therapeutic value of targeting M-CSF, we tested whether blocking mTOR signaling (which is downstream M-CSF) would counteract the osteopenic disease in Sf mice.
Thus, somewhat ironically, the SPINK1 −81C>T variant may actually constitute a protective allele, the effect of which would have been counteracted by the CFTR alleles in this particular case.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com