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Particularly interesting were the cluster 4 and 7 genes, which were regulated by STATc and this regulation also dominated the transciptional output of wt cells (experiment I).
The final, relatively minor groups of regulated genes included genes which were regulated at both the transcriptional and the polyA mRNA levels in either the same (8.4%) or opposite directions (9%).
Apart from specifically regulated proteins we also identified sets of proteins which were regulated as a general response to drug treatment.
The target genes which were regulated by miRNAs through mRNA degradation are negatively correlated with the miRNA regulators.
The target genes which were regulated by miRNAs through mRNA degradation are anti-correlated with the miRNA regulators.
Apart from signaling cascades directly linked to initial membrane signal (e.g., ErbB2, ITG5A, c-Met), other multi-functional hubs (e.g., AKT, Raf, ATR, PI3K) and transcriptional regulators (e.g., Mef2D, TP53, ELK3, ATF7) were identified, most of which were regulated in a tumor case-specific manner.
Similar(13)
Similar problems are cropping up at registered investment advisers, which are regulated by the SEC and by state regulators.
The Washington regulators do not have jurisdiction over the insurance companies, which are regulated state by state.
"We're in cable television, which is regulated.
Then there's the BBC, which is regulated by a mixture of the BBC Trust and Ofcom.
Each New York State city creates its own health code, which is regulated by the Board of Health.
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