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However, human HNSCC, are often deficient in PTEN, and show infiltration of inflammatory monocytes, angiogenesis and NF- κB activation, which were recapitulated in mice deficient in Pten and Tgfbr1.
The sEH inhibitors TPPU or AUDA inhibited LPS-induced NFκB activation and iNOS induction in mSMC, but had no effect on NFκB nuclear localization or inducible nitric oxide synthase in iSMC; effects which were recapitulated in part by addition of authentic epoxy-oxylipins.
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Since its description in 1957 in two patients with bronchogenic carcinoma [173], SIADH has been described as an epiphenomenon of a broad range of conditions and diseases which are recapitulated in Table 3.
However, this panel could be substantially refined in the future given the prevalence of recurrent copy number aberrations in driver genes seen in Fig. 1, and the recurrent promoter methylation in lung cancer (Belinsky 2004) which is recapitulated in ctDNA (Mishima et al. 2015; Warton et al. 2016).
Notable amongst these was the conversion of α-ketoglutarate to succinate which was recapitulated by the treatment of cell extracts with exogenous hydrogen peroxide.
We previously described an inverse relationship between H4K20me1 and H4K20me3 in the myotome of mid-gestation mouse embryos, which was recapitulated in primary myoblast cultures.
This suggests that cr3′ss+126 is selected with an appreciable frequency in vivo, which was recapitulated in our reporters (Fig. 1d).
In the present study we use the MSOR nomenclature introduced in ref. [ 39] which is recapitulated in Figure 1A.
Cells with a PHC1 mutation also enhanced the geminin expression, which was recapitulated in RNAi experiments in control and patient cells in which PHC1 was ectopically expressed.
One possibility is that these proteins interact with NEMO in a dynamic manner, which is recapitulated differently between the in vitro and 'in vivo' experiments.
Previous studies in several species including Drosophila and Arabidopsis [ 27, 37, 41, 80] have shown that first introns tend to be the longest and the most conserved, which is recapitulated in human by our study.
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