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Using this approach, we have discovered six novel TAR-binding fragments, three of which were docked relative to the probe RNA structure using experimental NMR restraints.
One such experiment we report was conducted using the FlexX docking algorithm on a variety of data sets containing COX-2 inhibitors as well as randomly selected inactive molecules which were docked into the COX-2 crystal structure to test the predictive power of scoring functions available in either FlexX or CScore.
In control mice, axon terminals were filled with synaptic vesicles, some of which were docked on electron-dense active zones.
LigPrep generated 5,636 3D structures with variations in, e.g., tautomeric and ionic form, which were docked flexibly in standard precision-mode in Glide (Glide version 5.6.107) to the generated receptor grid of each of the five-protein 3D structures.
We generated a model of the FAK and p53 interaction and performed screening of >200,000 small molecule compounds from the National Cancer Institute database, which were docked into the region of the FAK and p53 interaction.
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Intrepid, which is docked in the Hudson River, off midtown Manhattan.
Iwo Jima, which was docked in New York for the Navy's annual Fleet Week.
Later that day, he invited Ms. Chan to a party on his yacht, which was docked in Sag Harbor.
Among the 10,000 people aboard the Enterprise, which was docked at Norfolk's naval station, were 25 survivors of the Pearl Harbor attack.
His Batmobile is a 36-foot diesel motor launch, a former lobster boat designed for shell fishing in Delaware, which is docked in Nyack.
"They were significant landmarks that helped me navigate," said John Doswell, part owner of the retired fireboat John J. Harvey, which is docked at Pier 63.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com