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Diabetic myocytes exhibited enhanced levels of reactive oxygen species and apoptosis, which were alleviated by catalase.
Chronic alcohol intake led to glucose intolerance, reduced glucose uptake, cardiac hypertrophy and reduced cell shortening, the effects of which were alleviated by ALDH2.
Doxorubicin challenge compromised mitochondrial integrity and upregulated 4-HNE and UCP-2 levels while downregulating levels of TRPV1, SERCA2a and PGC-1α, the effects of which were alleviated by ALDH2.
ER stress led to compromised echocardiographic indices (elevated LVESD, reduced fractional shortening and cardiac output), cardiomyocyte contractile and intracellular Ca2 + properties and cell survival, associated with upregulated autophagy, dampened phosphorylation of Akt and its downstream signal molecules TSC2 and mTOR, the effects of which were alleviated or mitigated by ALDH2.
High fat diet intake compromised cardiomyocyte contractile function as evidenced by decreased peak shortening, maximal velocity of shortening/relengthening, intracellular Ca2 + release as well as prolonged duration of relengthening and intracellular Ca2 + decay, the effects of which were alleviated by PTP1B knockout.
Reflux and bleeding (after stent removal) were observed in 15 (20%) and 9 (12%) patient, respectively, both of which were alleviated or disappeared spontaneously following stent removal without additional treatment.
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Lectin staining displayed that diabetes promoted cardiac hypertrophy, the effect of which was alleviated by ALDH2.
Abnormal cerebellar input to VIM is presumed to be a major contributor to tremor symptoms, which is alleviated by DBS.
The ratio of liver to body weight was increased by chronic-binge ethanol exposure as compared with pair-fed group, which was alleviated by AXT administration (Fig. 1C).
Seasonal affective disorder is characterized by the onset of depressive symptoms in autumn and winter, which are alleviated with increased exposure to natural light in spring and summer.
The hypothesis that increase in dietary phytin amplifies phytin binding to protein thereby reducing protein digestion, which is alleviated by phytase, was tested.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com