The diseases associated with these genes include Menkes and Wilson's disease, both of which are caused by mutations in genes orthologous to yeast CCC2, and both of which are well established Cu-related disorders [ 9, 11].
Likewise, the roles of pathways including Rapsyn, Dok7, MuSK, and Tid1, which are well established at the NMJ (Wu et al., 2010), have no well-established roles at CNS synapses.
Here, G is an inner-product kernel which allows to perform all computations in the space of n genotypes instead of p SNPs, a shortcut which is well established in the field of kernel-based machine learning [ 38].
No one disputes the link between poverty and AIDS, which is well established.
Choc ice, Bounty bars etc, are harmless words on the surface, unlike the N-word, which is well established as a racial slur.
I inherited a number of processes, some of which were well established and effective and some where I could see they created more work for my team.
"We lose out not only to men's rugby, but to netball, which is well established as the top female sport," said the team's captain, Melissa Ruscoe.
The fourth edition of the American Heritage Dictionary labels plus which "not well established in formal writing"; its editor, Joe Pickett, calls the usage "a bizarre construction that combines two conjunctions and has the force of a conjunctive adverb" (indeed!).
There are more than 600 music therapists in the UK but because of lack of high-quality research it has lagged behind art therapy, which is well established in many units dealing with mental health problems and dementia.
The British brand Topshop, which is well established in other parts of Asia — it has eight shops each in Indonesia and Malaysia, six in Singapore and four in Japan, among others — is opening its first store in Hong Kong this year, in May.
In 1923, when de Broglie put forward this idea, there was no experimental evidence whatsoever that the electron, the corpuscular properties of which were well established by experiment, might under some conditions behave as if it were radiant energy.
