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We developed a decision tree model by using data from a 2-year period (development cohort, 2008 and 2009, n = 3,693), which we validated using external data from 2010 (validation cohort, n = 1,686).
Therefore, we set up an experiment in which we validated our classifier on independent data from the same institution (intra-dataset validation), a combination of institutions (cross-dataset validation), and by validating on data from different institutions (inter-dataset validation).
Similar to drm mutants, no effect on methylation was recently reported for P. patens rdr2 mutant35, which we validated here while substantially expanding our analysis to a larger genomic portion (80 vs. 20%; Supplementary Fig. 8a and Supplementary Table 2).
Our techniques are instantiated in a system for network incident investigation, Isis, which we validated with a long-term collaboration and deployment with the principal network analyst of the EE and CS departments at Stanford University.
Similar to M10 OL1, the M10 O1 complex displays a chevron-shaped antiparallel Ig Ig architecture held together by a conserved molecular interface, which we validated by isothermal titration calorimetry and sorting experiments in neonatal rat cardiomyocytes.
A second way in which we validated our work is to compare it with the standard R statistical toolbox, and specifically the outlier function in the outliers package.
Similar(23)
The model predicts the location of a polarity determinant BASL over multiple divisions, which we validate experimentally.
We develop techniques to automatically identify these misnamings, and determine the actual locations, which we validate against the configuration of the ISP's routers.
This network model predicts a functional interaction between the transcription factor Jun and the IRE1 kinase, which we validate in an orthogonal assay.
We discover conserved structured elements in 35% of UTRs, several of which we validate as novel protein binding motifs.
We conditionally confirm the theoretical prediction ζ ≈ 1/b13,34,35,36,37,38, which we validate only in the case that the extremely rare "unlimited" lexicon words are not included in the data sample (see Figs. 3 and 4).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com