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Leakes and Whitfield were in the midst of a personal conflict, which was escalated after Leakes was excluded from Whitfield's divorce party.
Patients randomly assigned to methotrexate arms received 7.5 mg methotrexate once a week, which was escalated to 20 mg once a week over 8 weeks.
At inclusion (baseline), all patients started treatment with methotrexate (MTX) at a dose of 10 mg weekly, which was escalated every 2 weeks by 5 mg up to 20 mg weekly as target dose.
EM and PM were separately enrolled to respective cohorts testing the initial dose of 120 mg BID, which was escalated to up to 240 mg BID in accordance with the 3 + 3 rule.
Pregnant women were typically started on a low-dose regimen of DES, which was escalated every 2 weeks to a maximum dose of 0.15 g/day until the end of the pregnancy [ 8].
Patients were treated initially with a dose of 20 mg/m, which was escalated to 25 mg/m in those patients who did not incur a significant adverse event during the first cycle of therapy.
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There were 695 alarms in total, 431 (62%) of which were escalated to the call center.
These failures are extremely harmful for local socioeconomic systems which are escalated by ecological vulnerabilities of flooding, drought, river bank erosion, salinity intrusion, and charland.
"Medicare's insolvency is a symptom of the disease, which is escalating costs throughout our health care system," Mr. Sloane said.
Urbanization is leading to tighter spatial interrelationships among buildings, which is escalating building energy consumption due to the impact of buildings on one another.
Scenes from #solidaritywithrefugees as Camden residents community groups&cllrs join the rally #refugeeswelcome pic.twitter.com/s2eaC148uW The rally comes two days ahead of a summit of European leaders in Brussels to deal with the crisis, which is escalating across Europe.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com