Sentence examples for which was efficacious from inspiring English sources

Structure activity relationship studies led to the identification of 10c, which was efficacious in a diabetic ob/ob mouse model and reduced fasting and non-fasting blood glucose levels after ip dosing.

These efforts produced a potent and selective CHOP inducer (AC50 = 0.8 μM; XBP1 > 80 μM), which was efficacious in both mouse embryonic fibroblast cells and a human oral squamous cell cancer cell line, and demonstrated antiproliferative effects for multiple cancer cell lines in the NCI-60 panel.

Moreover, in contrast to many other animal tumours studied, which used high doses of BPs (Guenther et al, 2002; Croucher et al, 2003), the zoledronic acid dose of 20  μg kg−1 week−1 s.c., which was efficacious in the murine plasmacytoma model is approximately equivalent to the approved clinical dose for the treatment of the skeletal complications of MM (4 mg every 3 4 weeks i.v).v

More recently, diverse prophylactic drugs, which are efficacious for the prophylactic treatment of MwA and MwoA, have been shown to experimentally suppress SD susceptibility.

In conclusion, telephone-based guided self-help is an acceptable minimal intervention which is efficacious in reducing fatigue in adolescents with CFS.

Remarkably, we obtained compounds with enzyme inhibition values (IC50) as low as 2 nM, which were efficacious against wild type and multidrug-resistant strains of T. brucei and T. congolense.

In this study, we determined the effect of new phenylalanine-derived (Z -5-arylmethylidene Z -5-arylmethylidene Z -5-arylmethylidene Mrhodaninese activity of the twhichpe II bareefficacioussomeragainstNA gyrase and topoisoMRSAse IV (Tono IV).

Montelukast, a newer leukotriene antagonist, which is efficacious and safe in patients with asthma 6 years of age and older, has not been reported as therapy for atopic dermatitis.

BMS-189664 (3) is identified as a potent, selective, and orally active reversible inhibitor of human α-thrombin which is efficacious in vivo in a mouse lethality model, and at inhibiting both arterial and venous thrombosis in cynomolgus monkey models.

These vaccines elicit antibodies, primarily to the viral hemagglutinin (HA), which are efficacious in healthy adults, but are limited in protecting high risk individuals, such as the elderly and immunocompromised.

Macrolides, which are efficacious in treating Campylobacter (5, 34 ), should still be considered the first-line drugs for severe Campylobacter infections, as resistance to this class remains low.