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The cell viability of HeLa cells transfected with docetaxel-loaded NPs was decreased after 6 h, which was dose- and time-dependent.
The cotransfection with VRK2A, VRK2B (Fig. 2A, second box), or their kinase-dead (K169E substitution), variants that contain the K169E substitution in the catalytic site [40] (Fig. 2A, third box) resulted in a significant reduction of the transcriptional response to IL-1β, which was dose dependent, and consistent with the inhibitory role proposed for VRK2 in the previous section.
Additionally exogenous EGF only minimally affected the growth and DNA synthesis of DU145 cells whereas LNCaP cells showed a significant response which was dose dependent.
OA chondrocytes stimulated with IL-1β alone showed 504% increase in MMP-13 protein production, which was dose dependently inhibited (upto 49%) by HLM.
Coincubation of spermatozoa with sperm receptor showed a remarkable increase in reduction of ATP which was dose dependent, as the ATPase units rose from 812.67 ± 2.52 to 1472.67 ± 2.08 (P < 0.001) with increasing concentrations of receptor.
This study demonstrates that target-selective accumulation of Pan-IR700 in MDA-MB-468luc tumors resulted in rapid cell death, which was dose dependent based on the NIR light intensity in the range of 50-150 J/cm.
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Treatment of cells with 9-cis-RA potently induced the transactivation of RXRα homodimer, which was dose-dependently inhibited by N-6 (Fig. 2A).
Unilateral chronic constriction injury (CCI) to the sciatic nerve in rats produced an increase in the number of hind paw withdrawals from a cold surface (4 ± 2 °C) which was dose-dependently inhibited by systemic (i.p).
The first oral formulation from Hoechst Marion Roussel in 1975 was an immediate release tablet (Ditropan®), which was dosed three times a day.
The cellular response in whole-cell recording corresponded to a membrane potential of −80 mV and an inward current, the peak amplitude of which was dose-dependent.
As shown in Figure 2A, N2a-RML cells presented diminished ER calcium release after thapsigargin treatment, which was dose-dependent (Figure 2B).
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