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It was reported that a higher level of Hsp70 was associated with vRNPs of influenza A/Ann Arbor/6/60 virus which was defective in replication compared with those of rWT virus [41].
In both cases, there was not only an accumulation in the mutant which was defective in the subsequent metabolic reaction, however, also in the strain with an inability to perform the second next reaction.
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However, our results for the T557A mutant, which is defective in Plk1-binding and phosphorylation but does not show any localization defects, suggest that regulation of GCP-WD by Plk1 is not essential for spindle localization of γTuRCs.
Both OsPrxIIE2 and OsPrxQ were down-regulated in the dxr mutant, which is defective in the light response.
To characterize the new pathway, genetically modified human and mouse cells, which are defective in specific signaling proteins, were used.
So far, the strongest phenotype reported for a single glr mutant is in rice which is defective in the OsGLR3.1 gene (Li et al. 2006).
Double mutant of atabcg22 with other genes shows that atabcg22 can enhance the phenotypes of srk2e/ost1 and nced3 mutants, which are defective in ABA signaling and biosynthesis, respectively.
We have compared this with the effect of expressing a mutant form which is defective in PCNA-binding, but which retains the secondary cyclin CDK-inhibitory site.
But soon after it was approved, Gleevec was found to inhibit another tyrosine kinase called c-kit, which is defective in people with a rare gastrointestinal tumor.
Thus it appears that PKC phosphorylates and regulates two different sites on the channel or on an associated membrane protein, one of which is defective in cystic fibrosis.
In the rice mutant 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr), which is defective in the light response, downregulation of two PRX genes indicated the involvement of those proteins in DXR-mediated light signaling.
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