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Poliovirus infection remodels intracellular membranes, creating a large number of membranous vesicles on which viral RNA replication occurs.
The process by which viral proteins and nucleic acids come together in an infected cell to produce new virus particles.
We have developed a complementary approach in which viral and synthetic components are combined to form hybrid nanoparticulate vectors.
The manner in which viral vaccines are produced in a biological system makes them vulnerable to microbial contamination.
Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets.
They then determined that the stage at which viral replication was blocked in these cells was at early viral gene transcription.
They added that this would not be the first autoimmune disorder in which viral infections had suspected involvement.
The Bowie release highlights the musician's own mythmaking, mystery, and melancholy, but it also demonstrates the ways in which viral marketing and digital distribution have permanently changed the record business.
Control is achieved very early in the course of infection, but the mechanisms through which viral replication is restricted are not fully understood.
No BFA-resistant virus was detected in these experiments, further supporting the hypothesis that poliovirus replication requires secretory pathway function, perhaps for the generation of vesicles on which viral RNA replication complexes are assembled.
Here we show that in Drosophila cells, Drosophila C virus remodels the Golgi apparatus and forms a novel vesicular compartment, on the surface of which viral RNA replication takes place.
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