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First, in contrast to cAMP which triggers both rapid and delayed increases in cortisol synthesis through PKA-dependent mechanisms, 8CPT-2'-OMe-cAMP and its metabolites stimulate only delayed increases in cortisol without activating PKA [1], [13], [38].
This motif is unique within the 131 151 sequence, which triggers both intramolecular and intermolecular T and B cell diversification.
This association may be explained by the latent development of symptomatic disease, which triggers both the cessation of the study drug and decline in HSUVs.
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Samuelson's axiom held good until the collapse of Lehman Brothers, which triggered both an economic crisis and a crisis in economics.
Thus far, WHO's Director General has not declared it a "Public Health Emergency of International Concern" (PHEIC), which triggers consideration of both trade and travel restrictions, as well as international assistance and under the International Health Regulations.
Recent advances in molecular cell biology indicate that anticancer therapies promote cellular stress, which can trigger both autophagy and apoptosis.
After injury, an excessive amount of t-PA is released into the extracellular space of the brain, which can trigger both neuronal degeneration [ 23] and disruption of the BBB [ 24].
Although the mechanism remains unclear, when used to treat drug-resistant cases of malignant myeloma, bortezomib has been shown to induce endoplasmic reticulum (ER) stress, which can trigger both cell-cycle arrest and cell death (Obeng et al, 2006).
Both these proteases can proteolytically activate SERA5, which triggers downstream processing of cellular substrates [ 103, 104].
Both of these initiator caspases lead to downstream activation of executioner caspase-3 or -7, which triggers cell apoptosis [ 34].
A series of molecular signals which triggers the apoptotic death of a cell.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com