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Ice hockey is the only major sport in which substitutions are permitted while the game is in play.
The rate at which substitutions occur in a population is found by multiplying the number of mutations produced per generation with the probability that these mutations are fixed.
The rules RCEC and RCEA introduce a very weak requirement according to which substitutions by logically equivalent formulas is possible respectively in antecedents and consequents of conditionals.
Common to all methods for altering an existing protein is the selection of a subset of amino acids in the protein for variation and a choice of which substitutions to make at each position.
One exception to this pattern was Vif172 179RL8, in which substitutions affected either P2 or the C-terminus in each animal with epitope mutations.
The n-k landscape model, in which substitutions occurring on one of n sites affect the contribution of residues at k other sites to fitness, was proposed as a model of the fitness landscape [2], [3](Figure 1).
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This is different from the EDG-substituted derivatives, in which substitution at the 5-position results in the smallest IP.
There are two limiting mechanisms (or pathways) through which substitution may occur namely, dissociative and associative mechanisms.
Smaller mutations are more common and include point mutations, in which substitution of a single nucleotide base occurs, and deletion or insertion mutations, which involve several bases.
Molecular modelling studies of the chain conformation gave further insight into the mechanism by which substitution symmetry affects the polymer properties.
Also see Robert Bernasconi, "What is the Question to which 'Substitution' is the Answer?" in eds., Simon Critchley and Robert Bernasconi, The Cambridge Companion to Levinas (London, UK and New York, NY: Cambridge University Press, 1998), pp. 234-51.
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