Sentence examples for which substantially limits from inspiring English sources

It has to be sutured in place and is not resorbable, so it has to be removed at a second laparoscopy, which substantially limits its applicability in peritoneal surgery.

Previous investigations into the prevalence of psychological distress in AS patients have involved small patient samples 10 12 which substantially limits the representativeness and generalisability of their findings.

Development of resistance to carbapenems in Enterobacteriaceae organisms has been reported increasingly, which substantially limits treatment options for persons with multidrug-resistant gram-negative infections (8 ).

However, high-throughput sequencing equipment can currently only produce short DNA fragments (typically 75-400 nuclongides long) which substantially limits the sensitivity and specificity of identifying genes such as qnr[ 27].

While most states changed their renewal period, in-person renewal requirements, and vision testing requirements for some or all drivers at some point during the study period, there were few changes in requirements for drivers to pass a knowledge test or on-road driving test, which substantially limited the study's ability to detect any possible impact of these policies.

Rakoff, a Federal District Court judge, denied a motion by Irving H. Picard, the trustee for the victims of Madoff's fraud, to have his initial decision in the case — in which he substantially limited the amount of money the trustee can seek from the team's owners — immediately appealed.

One primary challenge in such a development is how to deal with the interference, which may substantially limit the reliability and the throughput of a wireless communication system.

Last month, I reported on two amendments put forward in the House Financial Services Committee which would substantially limit the undemocratic power of the Federal Reserve and the national bank regulator, the Office of the Comptroller of the Currency.

It is being considered for addition to the list of Persistent Organic Pollutants (POPs) under the Stockholm Convention, which would substantially limit its production and use.

Despite the above evidence that platelet specific miRNAs are associated with varied response to antiplatelet therapy, the detection of intraplatelet miRNAs requires a large amount of blood (15 20 mL), as well as a white blood cell depletion protocol using magnetic beads, which may substantially limit its clinical application.

For example, they say, the rule substantially limits the extent to which banks can reduce derivatives exposure by comparing what they owe on trades against what they are owed on other trades.