Typically, mutations in codons 514 and 521 cause mild delocalization and are found in late-onset ALS, whereas mutations in codons 525 (or 522), which strongly impair nuclear import, are associated with juvenile ALS forms (Dormann et al., 2010, 2012; Ito et al., 2010).
Many coastal areas can be considered over-stressed systems as a whole, the ecosystem services of which are strongly impaired.
These results highlight the effect of NT on cell migration, which is strongly impaired under hyperglycemic conditions, as well as its effect in decreasing the proinflammatory status of macrophages under hyperglycemic and inflammatory conditions.
Cytolytic functions of CTLs in vitro were largely intact in CD8+ T cells from Stim1 fl/fl Cd4Cre and Orai1 R93W knock-in mice (data not shown), which have strongly impaired but not abolished SOCE (McCarl et al, 2010; Oh-Hora et al, 2008).
Finally, destabilizing the intramolecular H-bond network with NaF strongly impaired the insertion of Aβ, which strongly supported the conclusions drawn on the basis of our modeling studies.
Iron constitutes an indispensable plant nutrient and severe deficiencies cause leaves to turn completely yellow or almost white, which in turn strongly impairs plant growth and leads to high yield losses [ 3, 5].
We have previously shown that lysine 713 has a critical function for TPO epitope recognition by mAb47 (Bresson et al, 2004), which is probably strongly impaired by cross-linking of the amino acid on formaldehyde slide fixation.
This strongly impairs the environmental friendly character of the resulting composite material.
However, restricting the polypeptides to the nucleus strongly impairs their NMD-inhibitory function, even for those intended to inhibit interactions between the exon-junction complex (EJC) and hUpf3 proteins, which localize primarily in the nucleus.
