The poor water solubility of vitexin limits its dissolution, which strongly impairs drug bioavailability.
Substantial variation of the reported incidence estimates suggest that the data are highly unreliable, which strongly impairs inter-country comparability as well.
Many coastal areas can be considered over-stressed systems as a whole, the ecosystem services of which are strongly impaired.
These results highlight the effect of NT on cell migration, which is strongly impaired under hyperglycemic conditions, as well as its effect in decreasing the proinflammatory status of macrophages under hyperglycemic and inflammatory conditions.
Cytolytic functions of CTLs in vitro were largely intact in CD8+ T cells from Stim1 fl/fl Cd4Cre and Orai1 R93W knock-in mice (data not shown), which have strongly impaired but not abolished SOCE (McCarl et al, 2010; Oh-Hora et al, 2008).
Finally, destabilizing the intramolecular H-bond network with NaF strongly impaired the insertion of Aβ, which strongly supported the conclusions drawn on the basis of our modeling studies.
Iron constitutes an indispensable plant nutrient and severe deficiencies cause leaves to turn completely yellow or almost white, which in turn strongly impairs plant growth and leads to high yield losses [ 3, 5].
We have previously shown that lysine 713 has a critical function for TPO epitope recognition by mAb47 (Bresson et al, 2004), which is probably strongly impaired by cross-linking of the amino acid on formaldehyde slide fixation.
Dams strongly impair the fluvial environment by altering downstream flows.
In addition, mutants in the P-loop were characterized that strongly impair binding of nucleotide.
