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The ACMG working group limited its list to genes that carry a high risk of disease for example, mutations in BRCA1 and BRCA2, which significantly raise the risk of breast and ovarian cancer, and for which extra screening and prophylactic surgery can reduce risk.
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There were glimmers of enlightenment even during those years: he railed against Georgia's inbred corruption and introduced mildly reformist economic policies, which significantly raised the republic's prosperity – bringing him to Gorbachev's attention in Moscow.
When evaluating eligibility, FEMA changed its usual phrase "as a result" to "as a direct result," which significantly raised the burden of proof on jobless workers and others trying to qualify.
In 1977, the library system started a New Americans Program to adapt to population shifts resulting from the 1965 immigration act, which significantly raised immigration from countries outside Europe.
The dilute nature of microalgal cultures means extensive dewatering is required prior to biomass processing, which significantly raises energy costs using current methods such as centrifugation, electrophoresis and floatation (Chisti and Yan, 2011).
The Democratic platform now calls for government funded legal representation for unaccompanied minors who cross into the U.S. illegally, which significantly raises their chances of winning asylum or other forms of humanitarian relief from deportation.
All three summary statistics have the added convenience that they increase in integer units (i.e., S, η 1, h ∈ ℕ), which significantly raises the number of instances where the values of these summary statistics are identical in both observed and simulated datasets (see below).
Among Nasdaq's potential merger partners or acquisition targets is CBOE, which would significantly raise its profile in services like options and indexes, according to a research note by Patrick O'Shaughnessy, an analyst at Raymond James.
As part of his plan, Trump has vowed to re-introduce high-risk pools, which can significantly raise rates for those with pre-existing conditions.
So September is shaping up to be a record-breaker, says Jonathan Visscher from the SMMT, which has significantly raised its forecast for 2013 registrations to 2.216m vehicles.
Caterpillar, which has significantly raised its executives' compensation because of its strong profits, defended its demands, saying many unionized workers were paid well above market rates.
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