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Our focus is primarily genetic or environmental perturbations in rodent models which show altered placental responsiveness between sexes.

The transgenic mice (mutPOLG Tg mice) harbor mtDNA defects in the brains, which show altered activities of serotonin and noradrenalin.

In addition to genes such as APC, HIC1 and RASSF1 which show altered DNA methylation, but no concomitant change in gene expression levels we found a number of genes to display altered gene expression levels but no concomitant change in DNA methylation.

Identifying two over-expressing lines, which show altered phosphate starvation responses, suggests similar cellular processes are being targeted [ 76].

Similarly, we compared the GO categories of those which show altered expression in the presence of dADA2bS, but are not affected in the dAda2b mutant.

Moreover, mGluR1/5 localize to cholesterol-sphingolipid membrane domains (Francesconi et al, 2009), which show altered composition in ASMko neuronal membranes (Galvan et al, 2008).

We quantified 1315 proteins with two or more unique peptides, 116 of which showed altered changes.

This network is functionally associated with cancer, cellular development, cellular growth and proliferation (Figure S4), and is centered on a number of transcription factors and growth hormones (e.g. NCOR2, GH1, TGFβ1, HNF4A), and TP53 which shows altered DNA methylation in renal tissue of IUGR rats in adult life [26].

However PPARγ which showed altered expression levels on micorarray analysis was not changed as measured by QPCR.

Genes characterising these cell types have been identified, some of which showed altered expression levels in the malignant compared to the normal breast epithelium.

To identify such genes we performed expression profiling and focused specifically on miRNAs, several of which showed altered levels with age (Tables 1- 2).