After peripheral nerve injury, glial cells were activated immediately and secreted massive inflammatory and neurotransmitter mediators, which sensitized neuron and furtherly aggravated central sensitization [35, 36].
Joint inflammation in OA causes an increased synthesis of cyclooxygenase (COX -2-dependent COX -2-dependent COX -2-dependenttize prostaglandinsicePGsr terminals and produce localized sensitivity to pain [ 4].
The emission of intrinsic white light which sensitize the cancer cells, when excited by UV light is investigated.
Chi-Med's second compound, which sensitizes head and neck cancer cells to radiation, is approved for use in China.
The elevation of iCa2+ triggers the exocytosis of inflammatory mediators and stimulates both Ca2+/calmodulin-dependent kinase II (CAMKII) and calcineurin, which sensitize and desensitize TRPV1, respectively.
These neurons have an "amazing" property, called invariance, which sensitizes them not just to one image of their "preferred" stimulus, but to many different versions, Fried explains.
Activation of the D1 receptor leads to formation of cAMP [28] and subsequent activation of protein kinase A, which sensitizes tetrodotoxin (TTX -resistant Na+ channels [29], causing a pain response.
In addition, PAR-2-evoked mechanical and cold allodynia, as well as heat hyperalgesia, was found to be dependent on the PKA and PKC signaling pathways, which sensitize TRPA1 (Chen et al., 2011).
Jaesook et al. suggested that PTT may increase blood flow in tumors and reduce the hypoxic region, which sensitizes the tumor to radiotherapy [47], thus indicating that PTT is an excellent radiosensitizer.
