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Participants from academia, industry and regulatory bodies discussed which refinements of the test systems and screening approaches would be necessary or useful and which additional research is needed to improve bioaccumulation assessment (B-assessment).
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So which refinement is more appropriate as a solution concept?
What story there is seems to concern the penetration of this world––the elite, remote, cold, and desperate world of the British upper classes, in which refinement at the surface masks cruelty and unhappiness.
As stated above, one level at which refinement of biological response to chemical stimulus can be achieved is through the interaction of nuclear receptors signalling, via auto- or trans-regulatory loops, or through competition for ligands and/or response elements.
Hereditary kidney cancer represents a prototypic illustration of this phenomenon, in which refinement of syndrome-specific histological subtypes has been instrumental in gene discovery efforts 30.
1 Methods in which refinement weights are modified for data in proportion to their sensitivity to the Flack parameter have also been described (Bernardinelli & Flack, 1985 ▶; Parsons, Wagner et al., 2012 ▶).
Tight NCS restraints were applied during the refinement, which included refinement of TLS parameters.
Standard refinement methods in which the refinement criterion is based on local error monitors fail due to the pulled character of the streamer front that propagates into a linearly unstable state.
In this paper, we will present some operator reverse AM-GM inequalities which are refinements of (1.1), (1.6) and (1.7).
We proposed and proved new inequalities which represent refinements and generalizations of the inequalities stated in [2], related to Wilker Cusa–Huygens's inequalities.
In [2], Alomari et al. established Hermite-Hadamard-type inequalities for quasi-convex functions which give refinements of those given above in Theorem 4 and Theorem 5.
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