However, only 2 evaluations reported using randomized designs, one of which randomized only 4 clusters, and the authors also note the potential for publication bias.
The Costa Rica Vaccine Trial (CVT) was a randomized clinical trial conducted between 2004 and 2010, which randomized 7466 women aged 18 to 25 to receive the bivalent HPV-16/18 HPV-16/18r control Hepatitis-A vaccine.
The randomized studies of OAC in high-risk patients include the EAFT trial, which randomized 669 patients with non-rheumatic AF and a recent TIA or minor ischaemic stroke and found warfarin superior to both aspirin and placebo.
Full-consensus designed ankyrin repeat proteins (DARPins), in which randomized positions of the previously described DARPin library have been fixed, are characterized.
The SYMPLICITY HTN-3 trial, which randomized subjects to renal denervation (RDN) or sham control, was designed to evaluate the efficacy and safety of RDN for the treatment of resistant hypertension.
Forel et al. [8] demonstrated this result in a 2006 study, which randomized 36 patient to 48 hours of NMBA versus placebo and compared their bronchoalveolar lavage (BAL) and serum at 0 and 48 hours for statistical differences in inflammatory markers.
Our results are also similar to a retrospective analysis of the multicenter ALVEOLI trial, which randomized 549 patients with acute lung injury/ARDS to a high PEEP or a lower PEEP strategy, and found no difference in survival between the two groups [9],[9]].
A post-hoc subgroup analysis of the Women's Health Study, which randomized 100 mg aspirin on alternate days in primary prevention of CVD among 39,876 women aged ≥ 45 years, showed that aspirin reduced the risk of ischaemic stroke (RR, 0.76, 95% CI 0.63-0.93) but not of other CVD.
To determine the effects of late surfactant on respiratory outcomes determined at 1-year corrected age in the Trial of Late Surfactant (TOLSURF), which randomized newborns of extremely low gestational age (≤28 weeks' gestational age) ventilated at 7-14 days to late surfactant and inhaled nitric oxide vs inhaled nitric oxide-alone (control).
Quality registers enable scientific assessments in areas for which randomized, controlled trials are not always possible [ 4].
Out of the 11 EP studies there was just one [ 17] which randomized the participants to the three experimental conditions.
