It has been demonstrated, for example, that high-activity CYP3A4 (cytochrome P450 3alleleseles, which primarily metabolize testosterone, are associated with early puberty and are more common in African-American than Hispanic or white girls (Kadlubar et al. 2003).
These data clearly demonstrate that increased HKI activity, which is primarily associated with mitochondria, increases glucose metabolism, while increased HKII activity, which is found at least in part in the cytosol, slows glucose metabolism.
It has been proposed that PA stimulates PIP5-kinase which is primarily associated with the plasma membrane [18] and generates phosphatidylinositol 4,5-bisphosphate (phosphatidylinositol 4,5-bisphosphate in recePIP2 endocytosis.
3D-printing is another digital technology which, although primarily associated with manufacturing, can be used in the not too distant future to print food and medicine.
Consistent with these findings, Gu et al. (2015) observed greater mortality of drought-tolerant Q. alba and Q. rubra compared with other drought-sensitive and intolerant species (A. saccharum, F. americana) following an extreme drought in 2012, which was primarily associated with the lack of regulation of predawn water potential of the drought-tolerant species.
Interestingly, the STb subtype, which is primarily associated with diarrhea in piglets, binds to sulfatide [23].
Another markedly downregulated "male-specific" gene related to oxidative stress response was SOD1, which is primarily associated with amyotrophic lateral sclerosis (ALS), but common pathways with PD have been suggested [34].
For this purpose we performed an analysis of the associated SNPs, conditioning on the alleles of the protective and deleterious haplotypes which are primarily associated (see the paragraph "Analysis of the ancestral haplotypes").
For instance, mice that over-express human TNF within the thymus exhibit thymic atrophy, which is primarily associated with premature apoptosis of double negative (DN2) developing thymocytes and diminished numbers of cortical thymic epithelial cells (cTECs) [56].
Although principally known as the architects of coral reefs, the order Scleractinia, or stony corals, comprises two distinct ecological groups: the zooxanthellate species that live in symbiosis with a photosynthetic dinoflagellate occur in shallow tropical waters; and the azooxanthellate species, which are primarily associated with deeper and colder waters.
