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The specificity of KLK9 remains still unclear, as it cleaved P1 Arg containing pro-KLKs at very slow rates [20], while enzymatic data are only available for the rat ortholog rKLK9 (Table 1) [111,112], which possesses as major determinant of P1 specificity an Asp189, in contrast to the unusual Gly189 of human KLK9 (Fig. 1).
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For example, the pyridine 50, which possesses activity as a COX-2 inhibitor (<0.5 m m activity, >100 fold selectivity for COX-2 versus COX-1) 29 for the treatment of depressive disorders, can be made in 49%% yield over two synthetic steps from the α,β-unsaturated ketimine 49 (14 % overall yield from commercially available starting materials, Scheme 4).
A novel robust fault diagnosis scheme, which possesses fault estimate capability as well as fault diagnosis property, is proposed.
The recombinant Chlorobium tepidum ferritin (rCtFtn) is a structurally interesting protein since sequence alignments with other ferritins show that this protein has a significantly extended C-terminus, which possesses 12 histidine residues as well as several aspartate and glutamic acid residues that are potential metal ion binding residues.
The proposed network, which possesses the fuzzy inputs as well the fuzzy weights, integrates the self-organizing feature map (SOM) neural network and the fuzzy set theory.
A cluster head is an advanced cognitive user who manages a certain number of cognitive users, which possesses the functions as manager of its sub-network cognitive users' trust value and reporting to FC.
A novel series of potent and efficacious factor Xa inhibitors which possesses pyrrole/indole/thiazole moieties as S4 binding element was identified.
Extract and fractions used in this experiment exhibit the scavenging of hydroxyl radicals suggesting the presence of primary antioxidants which possess anti hemolytic as well as anti-lipid peroxidation potential.
These nanoparticles are spherical 50 nm silica-based and have been synthesized by the Stöber method with or without a cobalt ferrite core, which possess magnetic properties, as well as fluorescent rhodamine B incorporated into the silica shell and with or without a surface modification of poly ethylene glycol) (PEG).
Being structurally distant to ATP due to the pyrimidine ring, CTP's stronger binding to CoaE relative to GTP, which possesses a purine ring as ATP, came as a surprise.
Electrochemical investigations of a tri-iron cluster, [Fe3 μ3-S 2 CO 9 Fe3 μ3-S 2 CO 9 Fe3CO thereafter), which possesses a core of [FeIIFeIFeI], is designated
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