Sentence examples for which often necessitates from inspiring English sources

However, its use as a delivery agent in clinical trials for cancer treatment has been less successful, perhaps due to limited gene carrying capacity (~2 μg per dose), which often necessitates multiple immunisations at different sites in the body, reducing patient compliance [52 54].

In addition, ceramic head fractures pose a serious complication which often necessitates major revision surgery.

For example, the PKs of many biological agents are highly dependent on the PD response, which often necessitates simultaneous fitting of the data.

Older individuals use more medications than any other age group. 1 They typically suffer from multiple acute and chronic diseases, which often necessitates the use of multiple concomitant medications.

In addition, some evidence suggests body mass may influence prosthesis longevity, and/or the proclivity to dislocation, fracture, inactivity, and infection, which often necessitates surgical relocation, prosthetic removal, and reimplantation, differentially.

The typically poor prognosis of such infections is (besides delayed diagnosis) predominantly due to the low susceptibility of these fungi to commonly used antifungal agents (Chouaki et al. 2002; Kratzer et al. 2006), which often necessitates combined treatment with different drugs (Kratzer et al. 2006; Alanio et al. 2008).

Currently, researchers mostly use HPLC methods which often necessitate sample preparation, are not stereospecific and do not allow high throughput.

Infected pelvic hematoma is a relatively common complication of vaginal hysterectomy, manifesting with postoperative pain and fever which often necessitate surgical drainage.

Pharmacologic, nutritional and surgical treatments available to patients require adherence to prescribed regimens which often necessitate adjustment in daily activity.

It paves the way for the use of DsRed-based monomeric RFPs in transgenic and gene targeted approaches which often necessitate spatially and/or temporally restricted reporter expression.

That, in turn, necessitates that all marijuana businesses operate strictly in cash, which often leads to robberies and muggings.