The aforementioned findings demonstrate that Ras is an upstream regulator of RbAp46 which negatively regulates RECK expression at the transcriptional level.
We also identified transcripts associated with cell cycle regulation, like annexin I, which negatively regulates cyclin D1 gene expression [ 26] (Additional file 1, Table S2).
Recent studies demonstrated that the PA28γ-proteasome system is involved in regulation of aging thru degradation of casein kinase 1 (CK1), which negatively regulates Mdm2.
Furthermore, polyubiquitylated Rip2 is a substrate for the deubiquitylating enzyme A20, which negatively regulates Nod2 signaling (Hitotsumatsu et al., 2008).
BKI1 is the only reported inhibitor of receptor kinases in Arabidopsis, which negatively regulates BRI1 in the brassinosteroid pathway.
Huang et al. (2009) have isolated DST (drought and salt tolerance) gene, which negatively regulates stomatal closure and directs modulation of genes related to H2O2 homeostasis.
From the present study, miR-21 emerges as a new angiomiR which negatively regulates angiogenesis.
PARVB, encodes beta-parvin, which negatively regulates integrin-linked kinase (ILK) activity in breast cancer cells [69].
Pref-1, which negatively regulates adipogenesis, was not detected in lean, or AMP-DNM treated LepOb mice.
PTEN has a phosphatase domain [18], which negatively regulates PI3 kinase/Akt pathway by dephosphorylating PIP3 [20], [20].
The expression of Igfbp2 gene, which negatively regulates the biological activity of IGF1, was 6× (SQ) and 16× (ICV) upregulated after leptin replacement.
