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There are some potential limitations with our study, which need discussion.
However, a number of these may require discussion between the two reviewers as they could be pivotal papers which need discussion to integrate into the review.
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Based on our in vitro and in vivo results there are certain points which need further discussion regarding the tumor growth inhibition after drug treatments.
Two main themes emerged from this discussion, which need to be carefully considered in terms of the timing and multi-faceted nature of assessment; 1) that change needs to be about relationship change, placing parents/carers outcomes as central and 2) that change is multi-faceted and non-linear with progress as a complex journey with set-backs along the way.
However, this short communication provides discussion points, which need to be considered when using the acetone-induced barrier disruption method.
However, a number of choices need discussion.
We need discussion.
Several points need discussion.
By definition, for the upper curve T, we have γ 1 T = 0 ; equivalently, ψ 1 T = − π / 2. Equation (2.1) determines the height u 2 T. The counterpart for negative solutions is the curve IV at the bottom, which needs a bit more discussion.
Although the authors claim that the size of TCR clusters and the role of concatenated islands in T cell activation is established doctrine, in fact it remains a hypothesis and should be explained as such in the discussion, which needs to be much more balanced.
Finally, we provide a future perspective of this technique for the analysis of soft and dynamic nanomaterials and discussion the progress which needs to be made in order to bring in situ liquid TEM to its full potential.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com