Selectin-ligand interactions, which mediate rolling, are believed to be important for facilitating firm adhesion, either by activating integrins or by facilitating the transition to firm adhesion by making it easier for integrins to bind.
PSGL-1-mediated adhesion to selectin on endothelial cells mediates rolling and capture of neutrophils [1], [2].
Selectins are involved in the trafficking of T lymphocytes, and the interaction of selectins with their ligands mediates rolling of lymphocytes on the endothelium.
It mediates rolling of IEs on endothelial cells and facilitates adhesion to CD36 in field isolates from Thailand (Refs 54, 56, 88).
SELL (selectin L, CD62L antigen, up-regulated 3.90-fold in lung) is a cell surface adhesion protein which mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes and promotes the initial tethering and rolling of leukocytes in endothelia.
Rafsanjani is head of Iran's expediency council, which mediates between the parliament and the Guardian Council.
But large areas of her cerebrum, which mediates consciousness, language, and voluntary movements, were structurally intact.
Adhesion molecules mediate rolling and adhesion of homing cells to the blood vessel wall [ 27].
A recent connectomic study found that the connectivity of interneurons mediating rolling behavior in Drosophila larvae were reproducible between two individuals (Ohyama et al., 2015).
Under physiological conditions, terminally fucosylated glycans such as sLe-x function as selectin ligands, e.g. on activated leucocytes [ 33], and mediate rolling on and adhesion to ECs [ 34].
