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In this study, Gagne's instructional events were incorporated into Jonassen's model for designing constructivist learning environment (CLE) to enable collaborative learning, which mediated by web 2.0 tools.
Furthermore, the cardiovascular and metabolic effects of omega-3 PUFAs are widespread which mediated by its preventive mechanisms including the decrease in serum level of triglyceride, as well as increasing in the level of HDL level [ 12, 13].
In cell cycle progression relevant to cell proliferation, furthermore, the activation of p53 causes cell cycle arrest in the G1 phase, which mediated by p21 and p27, inhibitors of cyclin/CDK complexes [ 36, 37].
The formation of urea layer surrounding the cellulose chain, which mediated by different patterns of hydrogen bonding, was confirmed by radial distributing function and angular number distribution.
Subsequently, this lesion is stimulated by the release of various chemical factors that enhance the inflammatory response and, finally — depending on the type of aggression — acquired immunity is activated, which, mediated by lymphocyte participation, serves to establish a physical barrier against the propagation of the lesion and to aid repair of the damaged pulmonary tissue.
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The explanation for this could be that although early apoptotic cells remain morphologically intact, specific signals - such as expression of lysophosphatidylcholine - were upregulated on the cell surface, which mediated recognition by DCs and macrophages [ 36, 37].
Finally, repeated blood pressure measurements that induce repeated short arterial occlusion might have a role in the blood pressure decrease since transient ischemia during cuff inflation and reactive hyperemia after cuff deflation can induce dilation of upper arm artery, which is likely mediated by baroreceptor reflex and endothelium-dependent vasodilation21,22.
Comparison of the immune responses induced by P12A3C and FHG, which were both mediated by DNA plasmids, showed that FHG and P12A3C elicited similar cellular responses, while P12A3C induced higher antibody levels, suggesting that P12A3C is a more powerful immunogen than FHG.
Changes in baroreceptor reflex sensitivity may have counteracted these changes, which are likely mediated by increased peripheral vascular resistance.
NADPH activation increases ADMA levels by increasing protein methylation and inhibiting ADMA degradation, [ 18, 43] which are both mediated by reactive oxygen species.
However, these results indicate that there is a reduction in short-interval intracortical inhibition following aerobic exercise, which is likely mediated by exercise-induced changes in GABAA activity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com