New treatments which may involve poorly soluble drugs, easy biodegradable molecules and drugs endowed with systemic toxicity need highly specific delivery, i.e. targeting.
The most popular genres among mail-order renters, said Chris Lasala, who runs the mail-order operation, are classic films from the 40's and 50's, foreign films and gay films, all of which may be poorly represented -- or not represented at all -- in the average video store.
Uch37 progressively removes Ub from the distal part of the poly-Ub chain, which may rescue poorly ubiquitinated proteins from proteolysis (Lam et al., 1997; Koulich et al., 2008).
Moreover, an uncontoured fixed-angle locking plate must be used which may fit poorly on the bone.
However, prolonged otitis media and invasive bacterial infections, such as staphylococcal or pseudomonas septicaemia and pneumonia, may occur, which may respond poorly to appropriate treatment.
This observation provides useful insights into the mechanism of resistance to these novel agents, which may be poorly active on TRAP1-positive tumors.
There is also a need for a broader assessment of the value of self-management in the context of wider service redesign, as many models in this area highlight the interrelationships between patients, professionals, and the wider service context [ 13, 44], which may be poorly modelled by conventional trials.
In recent years European countries, specifically the UK, have experienced a substantial increase in migrants arriving from resource-poor countries [ 1]; countries which may have poorly-developed health-care systems and differing patterns of infectious disease and ill-health.
In pelvic MRI, respiration, cardiac motion and intestinal peristalsis often produce movement or ghosting artefacts which may result in poorly defined organ contours and reduced detection of pathological lesions.
Mutations conferring resistance to antibiotics target essential genes which may tolerate mutations poorly.
