Conversely, after IFN is discontinued, a small number of patients remain in cytogenetic or molecular remission for months to years without treatment [12], suggesting possible elimination of CML, or the persistence of residual undetectable LSC, which may be intrinsically constrained, controlled by indirect mechanisms that suppress growth, or both.
Even without xylose-co-feeding, p-hydroxybenzoate production was improved in the evolved xylose-utilizing strain, which may indicate an intrinsically elevated PP pathway activity.
We have observed that such FMD compounds are highly effective in DET reaction with weakly-bound electrons (unpublished data; Wang et al)., which may be either intrinsically rich in tumor cells/tissues or exogenously produced by ionizing radiation of biological systems.
However, the reported specific capacitance values for the various nanostructured MnO2 electrodes are still far below the theoretical value (approximately 1,370 F/g) [29], which may be attributed to the intrinsically poor electronic conductivity of MnO2.
However, studies have shown that the regions involved in protein protein interface formation are inherently flexible or intrinsically disordered, which may allow small molecules to diffuse in and disrupt the complex (Thangudu et al. 2012).
This finding supports the hypothesis that intrinsically disordered regions, which may correspond to natively unstructured regions, play a major role in the dynamics and diversity of TF networks [29], [30], [31], [32], [33].
List of the 1302 cancer proteins can be found in Supplementary File 2. The LWL, VFI, ConjunctiveRule, and DecisionStump were excluded from Case Study 1 because of their intrinsically high PPV which may bias the performance estimation.
In addition, APPG proteins are composed of long stretches of intrinsically-disordered domains, which may require "nanny" proteins to protect them from degradation (Tsvetkov et al., 2009).
NGAL is known to be released by activated neutrophils and appears to be intrinsically elevated in sepsis, which may explain its limitation as a biomarker specific for SSAKI.
In order to expand the depth and breadth of coverage in proteomics applications, in particular the ability to analyze intrinsically more acidic peptides which may be less effectively ionized in positive mode, negative mode offers an appealing option.
