Land subsidence caused by underground coalmining gives rise to severe surface deformation and results in a number of soil cracks, which markedly affect soil hydraulic properties; moreover, land rehabilitation is an effective measure to restore the ecological function of impacted lands.
Consequently, the currently observed reference flow values cannot be applied to patients with prior coronary revascularization procedures and/or heart failure, which markedly affect MBF values in the absence of significant coronary stenoses [ 38– 40].
In some individuals, susceptibility may be increased by rare inborn errors of GSH synthesis or by pathophysiological states which markedly affect GSH levels, e.g. hepatic failure, although any contrary effects on CYP2E1 activity would need to be taken into account.
The structure permeability was determined on the basis of the permeability coefficient which markedly affects the mass transport rate in the course of determination of the dissolution rate in vitro.
We discovered that when pCRP subunits are separated, they undergo a notable conformational change which markedly affects CRP solubility, antigenicity, biodistribution, cellular, and humoral reactivities (Potempa et al. 1983 , 1987 Ying et al. 1989; Schwedler et al. 2006; Wu et al. 2007; Wang et al. 2011).
A larger number of serious diseases occur in poplar, particularly foliar rust disease induced through infections with the rust fungus Melampsora spp., which markedly affects the growth of seeding and saplings.
The most informative mutations in this respect are the M64T/R76P CaM-NLS and R133W β-NLS (see [ 10]) mutations, none of which markedly affects DNA binding and bending, all only specifically impairing the nuclear import pathways mediated by the NLS in which they are mutated.
The interaction between these cells and their secreting factors results in an environment which markedly affects tumor progression.. Therefore, understanding the contribution of GPCRs and their ligands to the complexity of the tumor microenvironment is critical for the identification of novel therapeutic targets.
This phenomenon was due to the interaction between ions and the enzyme surface charge which could markedly affect the ionization of some amino acid residues, then change the enzyme conformation, and alter the enzyme activity.
Both rules were robust towards changes in parameter values, which did not markedly affect the outcomes.
Indeed, NE-deficient mice do not normally have seizures but display seizures upon the addition of a strong epileptic, such as PTZ, which does not markedly affect normal mice (Szot et al., 1999; Tully et al., 2007; Weinshenker et al., 2001).
