This is correct and usable in written English.
You can use it when expressing that something is making a situation or task more challenging or difficult. For example: The instructions were unclear, which makes difficult to complete the task.
These mixtures present very complex composition which makes difficult the description of the liquid liquid equilibrium involved.
The stress induced stabilisation mechanism is related to the presence of non-twinned γ′ martensite which makes difficult the retransformation to the parent phase.
The associated diffusion operator is hypoelliptic but not elliptic, which makes difficult the derivation of functional inequalities for the heat kernel.
In addition, unlike MIPv6, the routing in NEMO BS is suboptimal, which makes difficult the provision of an adequate service performance.
The number of possible chemical reactions grows exponentially with the number of chemical species, which makes difficult to select reactions that uniquely describe the data and diminishes the efficiency of the methods.
However, doubts emerge on the policy effectiveness of the current support scheme which makes difficult to control the total amount of support provided thus likely causing stop-and-go cycles of financing and potentially favouring distorted bidding behaviour.
Each solution is a unique development, which make difficult the cooperation process between labs.
These solutions present a structural instability which make difficult to approximate their evolution in long time intervals with enough accuracy.
Fish canning industry wastewaters have high organic matter, oil and grease and salt (NaCl) content, which make difficult a proper treatment before discharge.
Moreover, patients were given a combination of vasopressors with glucocorticoids, which made difficult to isolate the effect of glucocorticoids on the outcome.
He also hates chicken stock which makes cooking difficult.
