Ago2-SUMOylation was unaffected by mutation of K62, 65, 266 or 693 to arginine, but was very strongly reduced upon mutation of K402 (Fig. 2C), suggesting that Ago2 is primarily modified by SUMO at K402, which lies within the SUMOylation consensus sequence VKDE.
The northeastern Ozark Plateaus province, most of which lies in Missouri and Arkansas, has rough terrain and small fields devoted primarily to growing fruits and vegetables.
In contrast, psychologists have been primarily concerned with the development of the capacity for lying during childhood, our motives for lying, the incidence of lying in everyday life, and the means by which lies can be detected.
It says responsibility for examining the claim lies primarily with the member state which played the greatest part in the applicant's entry or residence in the EU.
However, the reviewers agree that the novelty lies primarily in the kinetic model which reveals, for instance, that trimerization is a rate-limiting step, rather than in the experimental approach or the general pathway involving dimer dissociation, trimerization etc.
The value they say they add lies primarily in peer review, the process through which works are assessed for validity and significance before publication.
The enforcement now lies primarily in the Trafficking Victim's Protection Act (TVPA), which was signed by the US Congress in 2000 and has been amended and improved upon five times since.
It must be reiterated that the strength of this study lies primarily in the identification of disease markers in peripheral blood cells, which is a preferred choice for the purpose of early diagnosis of TAA.
But, for me, her heroism lies primarily in her exposure of Kim Philby as a Soviet spy.
