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Beside the route of inoculation, our study involved the use of transgenic mice, which largely differ from the natural hosts of prion diseases, such as sheep, by the random insertion of transgene copies under the control of non prion regulatory sequences and in a murine genetic background.
In this study we report the BRCA1 and BRCA2 spectrum of mutations and their geographical distribution in Asturias, which largely differ from other areas of Spain.
Predictors of LV dysfunction after aortic valvular replacement have been investigated in four other studies which largely differ in their case-mix, hemodynamic treatments and criteria to define the main study endpoint [ 6- 8, 22].
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In this study, we have created the first picture of global PCOS research, which largely differs from other gynaecologic conditions and indicates that most related research and collaborations originate from high-income countries.
Muscle mass need not reflect muscle function, which largely differs and is dependent on the size, number, and contractility of fibers; fat infiltration; collagen content; etc. (48).
Structures which appear to largely differ in terms of 2D structure may give rise to quite similar steric/electrostatic properties (Fig. 4), which are what actually determine their recognition by biological macromolecules [2].
Although RS had the largest effects in terms of body weight gain and adiposity [26], there was no statistical difference between the two groups (which on the contrary largely differ in immune function [16]).
We obtained a similar value for the PDF+CRY+ ∩ PDF−CRY+ ∩ PDF−CRY− > CRYΔ genotype (tim-GAL4 > UAS-cryΔ), which argues against the assumption that these three drivers largely differ in their "strength" [ 13].
The members of the gene family largely differ, however, in the C-terminal region which has been implicated in self-association [ 3- 5].
In general, the shape of the duration ratios obtained largely differ from those presented in Kottke and Rathje [3], which follows the same shape of the over-prediction ratios (αAF, Fig. 8).
However, these trends largely differ across regions (e.g. developing economies have mostly reformed collective bargaining).
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