Together with let-7c, both miR-125 and miR-99 are over-expressed by at least 50% in the foetal hippocampus of individuals with Down syndrome compared to age and sex matched controls suggesting that miRNAs are playing an important role in this brain region, which is pertinent for learning and long-term memory formation [ 51].
The Framingham risk equations should continue to be used in the general population as 1) the equations did not overestimate risk by as much as the UKPDS Risk Engine in the normoglycemia and hyperglycemia groups and 2) they classified more participants correctly than the UKPDS Risk Engine, which is pertinent for statin prescribing.
In particular, a central question concerns the validity of biomarkers (and surrogate markers) and activity indices, which are pertinent for evaluating the performance of lupus trials [ 63, 64].
In line with empirical findings [ 48, 56, 57], our findings suggest that social integration and student-teacher interaction created a scaffold for relationships, which was pertinent for the educational environment.
The strengths of the current study include the assessment of clinically relevant outcomes, the long-term (1 year) treatment duration, and a treatment-free follow-up, which are pertinent for the management of patients with endometriosis.
The structural components of the eGC do not only interact with those plasma proteins which are pertinent for fluid homeosta-sis, as shown recently (28, 42), but also with small electrolytes, in particular with sodium.
A key challenge for Katz, which is pertinent to his line of work, is that he has been forced to live in a house-share for longer than he anticipated.
Male, 46, Occasional provider However, dentists have another professional duty which is pertinent where the patient is paying for health care and especially when the health care is of high cost, and this is the need to avoid marketing or selling unnecessary treatments.
There are exceptions for religious clothing, which is pertinent given Australia's recent political wrangling over Islamic attire.
"That which is pertinent is not funded," (participant 9, male).
Two such measures are the concordance index (C index) (22, 23) and the discrimination measure (D measure) (24), which are pertinent because of their relevant interpretation, familiarity for the intended clinical and epidemiologic audience, and low sensitivity to censoring in the absence of marked skewness of the linear predictor.
