In our previous study on mice, which were dosed with DE-71 at 45 mg/kg, 4-HO-BDE-42 was the most dominant metabolite of BDE-47 and accounted for 56% of the total HO-tetra-BDEs in mouse plasma, followed by 3-HO-BDE-47 (16%) and 4′-HO-BDE-49 (13%) (Qiu et al. 2007).
Extensive study of Eravci and coworkers [ 15] has shown significant changes in the hippocampal formation and amygdala in the key enzymes regulating the levels of thyroid hormones, deiodinases 2 (DIO2) and 3 (DIof) of the rats which were dosed with antidepressant and antipsychotic agents or subjected to a 24 h sleep deprivation, a commonly used nonpharmacological antidepressant treatment.
Such a regimen would provide increased convenience for patients compared with bosentan, which is dosed twice daily.
The principal dose-limiting toxicities of the combination therapy were the cutaneous side effect hand foot syndrome, which is characteristic of protracted infused fluoropyrimidines or capecitabine (which was designed to mimic continuous infusion of 5-FU), and neutropenia, which is dose limiting with single-agent paclitaxel.
If you need a breather, there's a grassy ramp you can roll down, and a room containing a gurgling, cut-glass fountain which, a framed certificate tells us, is dosed with a homeopathically minuscule quantity of LSD.
For many fruits and vegetables, freshness, weed control, and the variety grown may be far more important to taste than whether the soil in which they were grown was dosed with ammonium nitrate.
In the 1950s and 60s, US doctors helped the CIA design its now-discredited "mind control" programs, parts of which involved unwitting American citizens being dosed with LSD.
We were dosed with antibiotics, which worked on me almost at once.
Much more decadent are the "kiss and tell tarts" laced with vodka and the "flutter of green fairy cakes", which are liberally dosed with absinthe.
The urn contained a grapefruit granita, which was then dosed with a dash of the tequila as it was placed on the table.
Whether that be the young indie bands which populated the front row of his shows to the chagrin of uptight fashion editors banished to the rows behind them, or the designs themselves which are frequently dosed with gig culture – Glastonbury wellies and Courtney Love tiaras were a feature of his last show in Paris.
